Transdermal creams



Transdermal creams are the most commonly used form of progesterone therapy for a number of reasons, some of which are…

1: ease of use
2: cost effectiveness
3: can be used over a long term
4: direct benefit to the skin, making the use of other moisturizers unnecessary.

When using progesterone therapy it is essential to start on a high dose. Some practitioners give 2500mg/day for very severe cases of post-natal and manic depression, PMS, panic attacks, temporary psychosis etc.

After the initial high dose, which should bring relief in anywhere from three days to three months, it may gradually be reduced until the reappearance of symptoms.

This indicates the level of progesterone needed. As it is the precursor to the stress hormones any extra stress will require increased levels of progesterone therapy.

Once started on progesterone therapy you will become sensitive to the level needed on a daily basis. However, here is some additional guidance for you…

Important information: A study published in the American Journal of Obstetrics and Gynecology (June 1999, pages 1504–1511) states that “In order to obtain the proper (effective) serum levels with use of a progesterone cream, the cream needs to have an adequate amount of progesterone in it [at least 30 milligrams per gram]. Many over the counter creams have little [for example, 5 milligrams per ounce] or none at all. The creams that are made from Mexican yams are not metabolized to progesterone by women.”

– safe to use

Progesterone therapy has been practiced for over 50 years in the treatment of a wide variety of symptoms and diseases that are hormonally related. During this time no adverse side effects have been reported. Some people have benefited from it continuously for over 30 years.

There is no evidence to suggest it is possible to overdose using progesterone therapy.

Hormones are chemical messengers and can only work once inside the nucleus of a cell. To get into the nucleus the hormone needs a carrier which is called a receptor. Receptors are very specific, they will only transport the hormone for which they are made. Progesterone receptors will not transport the synthetic progestogens into the cell nor will they transport progesterone itself if there is adrenalin in the blood.

The level of progesterone varies in women from approximately 5mg per day in the first half of the monthly cycle up to 50 mg per day in the second half. During pregnancy the placenta produces up to 40 times the highest amount made when not pregnant. Men make from 5 to 15mg per day on a continuous basis.

– testing levels

Tests to find the level of progesterone in the blood of women are generally of little value for a number of reasons…

1: the ovary secretes progesterone in small spurts and the amount can vary within half an hour
2: low levels have been found in women who are not ovulating
3: if adrenalin is present or the blood sugar is too low even high levels of progesterone cannot be used
4: after a large meal the level of progesterone drops
5: the level drops during the long nights experienced in northern latitudes
6: progestogens contained in the Pill or HRT lower the level of progesterone

Progesterone therapy is usually administered in a cream or oil base, which means that it will be carried in the blood on a red blood cell membrane. Often tests only check the plasma which would show up little or no progesterone.

So what can you do for reliable results?

Saliva tests are generally more reliable. However, if you are a woman and if a blood test is your only option then make sure this is done during the 5 to 10 days before your next period. This is to check whether ovulation has occurred, as the level should then be at its highest point.

Read more:

Natural Progesterone v/s Progestins

Progesterone Therapy